Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis
Charlotte C Schmitt 1, Thomas Aranias 1, Thomas Viel 2, Danielle Chateau 1, Maude Le Gall 1,3, Anne-Judith Waligora-Dupriet 4, Chloé Melchior 5, Ophélie Rouxel 6, Nathalie Kapel 7, Guillaume Gourcerol 5, Bertrand Tavitian 2,8, Agnčs Lehuen 6, Edith Brot-Laroche 1, Armelle Leturque 1, Patricia Serradas 1, Alexandra Grosfeld 1 1INSERM UMR-S 1138 Centre de Recherche des Cordeliers, UPMC Univ Paris 06, 15 rue de l'Ecole de Medecine, 75006 Paris, France 2Plateforme d'Imageries du vivant PARCC - INSERM U970 - Université Paris Descartes, 56 rue Leblanc, 75015 Paris, France 3INSERM UMRS 1149 Université Paris Diderot, DHU Unity APHP, 16 rue Henri Huchard, 75018 Paris, France 4EA4065, Faculté de pharmacie Université Paris Descartes, 4 av. de l'Observatoire, 75006 Paris, France 5INSERM UMR-1073 Gastroenterology Department, Rouen University Hospital, 22 Bld Gambetta, 76183 Rouen, France 6INSERM U1016 and CNRS UMR8104 Institut Cochin, 22 Rue Mechain, 75014 Paris, France 7Service de Coprologie Fonctionnelle Hopital La Pitié Salpętričre, 47-83 Boulevard de l'Hôpital, 75013 Paris, France 8Service de Radiologie Hopital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
#PW 01 / 2
Predicting tissue-specific insulin sensitivity - a study combining [18F]FDG-PET and NMR-based metabolomic profiling Miikka-Juhani Honka 1, Robert M. Badeau 2, Jarna C. Hannukainen 1, Kari K. Kalliokoski 1, Kirsi A. Virtanen 1, Riikka Lautamäki 1, Antti P. Viljanen 1, Markus M. Lindroos 3, Pirjo Nuutila 1,4 1University of Turku Turku PET Centre, Kiinamyllynkatu 4-8, 20520 Turku, Finland 2Franklin Pierce University Health Sciences, 40 University Drive, Rindge, New Hampshire 03461, United States 3Turku University Hospital Department of Ophthalmology, Kiinamyllynkatu 4-8, 20520 Turku, Finland 4Turku University Hospital Department of Endocrinology, Kiinamyllynkatu 4-8, 20520 Turku, Finland
#PW 01 / 3
The human box C/D snoRNAs U3 and U8 are required for ribosome biogenesis and tumorigenesis. Gilles Doumont 1, Jean-Louis Langhendries 2 1Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles nuMIx, 8, rue Adrienne Bolland, B-6041 Charleroi (Gosselies), Belgium 2Université Libre de Bruxelles (ULB) RNA Molecular Biology, 12, rue des Professeurs Jeener et Brachet, 6041 Charleroi (Gosselies), Belgium
#PW 01 / 4
Glucose uptake in visceral adipose tissue is decreased in obese type 2 diabetic subjects compared to healthy obese subjects, as measured by 18F-FDG PET/CT.
Marti Boss 1, Hanne Rooijackers 2, Mijke Buitinga 1, Maarten Brom 1, Marcel Janssen 1, Anne Arens 1, Lioe-Fee de Geus-Oei 1, Liesbeth Salm 1, Bastiaan de Galan 2, Martin Gotthardt 1 1Radboud University Medical Center Nuclear Medicine, Geert Grooteplein Zuid 10, 6500HB Nijmegen, Netherlands 2Radboud University Medical Center Internal Medicine, Geert Grooteplein Zuid 10, 6500HB Nijmegen, Netherlands
#PW 01 / 5
13N-labelled amino acids as metabolic biomarkers in a mouse model of prostate cancer Rejc Luka1, da Silva Eunice S.1, Gómez-Vallejo Vanessa1, Baz Zurińe1, Zabala Amaia2, Carracedo Arkaitz2,3,4, López-Gallego Fernando4,5, Llop Jordi1 1CIC biomaGUNE, Radiochemistry and Nuclear Imaging Group - San Sebastian, Spain 2CIC bioGUNE - Derio, Spain 3University of the Basque Country, Biochemistry and Molecular Biology Department - Leioa, Spain 4IKERBASQUE, Basque Foundation for Science - Bilbao, Spain 5CIC biomaGUNE, Biofunctional Nanomaterials Unit - San Sebastian, Spain
#PW 01 / 6
DYNAMIC 31P-NMR REVEALS REDUCED MITOCHONDRIAL CAPACITIES FOR SCALLOPS' SWIMMING IN FUTURE OCEANS Christian Bock, Felizitas Wermter, Hans-Otto Pörtner, Gisela Lannig
Alfred Wegener Institute Helmholtz Center for Polar and Marine Research Integrative Ecophysiology, Am Handelshafen, 27570 Bremerhaven, Germany
#PW 01 / 7
Effect of Fasting on the Metabolome: A Standardization Approach
Ud-Dean S. M. Minhaz, Wenk Patricia, Disselhorst Jonathan A., Krueger Marcel A., Schmid Andreas M., Pichler Bernd J.
Werner Siemens Imaging Center, Departement of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University Tuebingen - Tuebingen, Germany
#PW 01 / 8
Quantitative Assessment of Radial Bone Structural Distribution in the Proximity of Degradable Implants by µCT within the MgBone Project Damm Timo1, Galli Silvia 2, Willumeit-Römer Regine 3, Glüer Claus-Christian 1 1University-Hospital Schleswig-Holstein Sektion Biomolecular Imaging - Kiel, Germany 2University of Malmö Faculty of Odontology - Malmö, Sweden 3Helmholtz-Zentrum Geesthacht Insitut für Werkstoffforschung - Geesthacht, Germany
#PW 01 / 9
Accelerated liver steatosis in eNOS-/- mice fed with high fat diet is reduced by aortic vascular injury Begona Lavin Plaza, Marcelo Andia, Thomas Eykyn, Alkystis Phinikaridou, Rene Botnar
King's College London Department of Biomedical Engineering, Westminster Bridge Road, St Thomas’ Hospital, Lambeth Wing, London, SE1 7EH, United Kingdom
#PW 01 / 10
Detection of tumorigenesis in mice implanted with human embryonic stem cells using serial [18F]FLT and [18F]FDG PET Foster Duncan1, Bantounas Ioannis2, Silajdzic Edina2, Ranjzad Parisa2, Lewis Philip2, Plagge Tony3, Asselin Marie-Claude4, Williams Steve C.4, Woolf Adrian S2,5, Kimber Susan J2 1Manchester Cancer Research Centre - Manchester, United Kingdom 2Division of Cell Matrix Biology and Regenerative Medicine, The University of Manchester - Manchester, United Kingdom 3University Of Liverpool - Liverpool, United Kingdom 4Division of Informatics, Imaging and Data Sciences,, The University of Manchester - Manchester, United Kingdom 5MAHSC and Royal Manchester Children’s Hospital - Manchester, United Kingdom
#PW 01 / 11
Dual 18FDG injection protocol shows changed glucose metabolism in the nucleus accumbens after cocaine challenge in rats. Bart de Laat 1,2, Willy Gsell 1,3, Cindy Casteels 1,2, Koen van Laere 1,2 1University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Leuven, Belgium 2University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Leuven, Belgium 3University of Leuven, Biomedical MRI unit, Leuven, Belgium
#PW 01 / 12
Different protocols of obesity evaluation and WAT quantification in a rat model of Diabetes
Patricia Gutierrez Carcedo 1, Anna Pujol Esclusa 2, Jose Raul Herance Camacho 1, Juan Antonio Camara Serrano 2 1Vall d´Hebron Institut de Recerca Molecular Imaging and Metabolism Researching Group, Ed. Recerca - Collserola | Planta 2 - Lab 205, 08035 Barcelona, Spain 2Vall d´Hebron Institut de Recerca Preclinical Imaging Platform, C/Nazaret, 115-117, 08035 Barcelona, Spain
#PW 01 / 13
A PET imaging and metabolomics-mass-spectrometry study to target ras-driven lung and colon tumours drug therapeutic response Silvia Valtorta 1,2,3, Marcella Bonanomi 3,4, Isabella Raccagni 3,5,6, Seth J. Parker 7, Christian Metallo 7,8, Lilia Alberghina 3,4, Daniela Gaglio 3,6, Rosa Maria Moresco 1,2,3 1University of Milano-Bicocca Department of Medicine and Surgery, Monza, Italy 2Institute of Bioimaging and Molecular Physiology, CNR, Segrate, Italy 3SYSBIO.IT, Centre of System Biology, Milano, Italy 4University of Milano-Bicocca Department of Biotechnology and Biosciences, Milano, Italy 5Tecnomed Foundation of University of Milano-Bicocca, Monza, Italy 6CNR Institute of Bioimaging and Molecular Phisiology, Segrate, Italy 7University of California Department of Bioengineering, San Diego, United States 8University of California Moores Cancer Center, San Diego, United States
Zinc iCEST MRI for Early Detection of Prostate Cancer Cells
Yue Yuan, Xiaolei Song, Jeff Bulte
Johns Hopkins University Radiology, 733 N. Broadway, Baltimore, Maryland 21205, United States
#PW 02 / 16
Plasma volume expanders as potential blood pool contrast agents for MRI-CEST applications
Lorena Consolino 1, Pietro Irrera 1, Annasofia Anemone 1, Silvio Aime 1, Dario Livio Longo 2 1Universitŕ di Torino Molecular Biotechnology and Health Sciences, Via Nizza 52, 10126 Torino, Italy 2National Research Council Institute of Biostructure and Bioimaging, Via Nizza 52, 10126 Torino, Italy
#PW 02 / 17
Highly efficient MRI agent to target fibrin/fibronectin complex in Prostate Adenocarcinoma Amerigo Pagoto, Rachele Stefania, Martina Tripepi, Stefania Lanzardo, Silvio Aime, Enzo Terreno
Universitŕ degli studi di Torino Department of Molecular Biotechnology and Health Sciences, Via Nizza 52, 10126 Torino, Italy
#PW 02 / 18
19F MRI-based detection of human mesenchymal stem cells (hMSC) labelled with fluorinated-PLGA nanoparticles
Hagberg Gisela1,2, Keliris Aneta1,3, Srinivas Mangala4, Schulz Hildegard1, Engelmann Joern1,3, Schmehl Jörg5, Bantleon Rüdiger5, Mannheim Julia6, Fuchs Kerstin6, Pichler Bernd J.6, van der Linden Annemie3, Scheffler Klaus1,2 1Max-Planck Institute for Biological Cybernetics, High Field Magnetic Resonance - Tübingen, Germany 2University Hospital Tübingen, Biomedical Magnetic Resonance - Tübingen, Germany 3University of Antwerpen, Bio-Imaging Lab - Antwerpen, Belgium 4Radboud University Nijmegen Medical Center, Tumor Immunology - Nijmegen, Netherlands 5University Hospital Tübingen, Diagnostic and Interventional Radiology - Tübingen, Germany 6University Hospital Tübingen, Preclinical Imaging and Radiopharmacy - Tübingen, Germany
#PW 02 / 19
Size-specific separation of iron oxide nanoparticles by selective centrifugation for optimized MRI, MPI and hyperthermia applications Seyed Mohammadali Dadfar 1, Denise Camozzi 2, Josbart Metselaar 1, Srinivas Banala 1, Nihan Güvener 1, Ioana Slabu 3, Ulrich Engelmann 3, Marcel Straub 1, Volkmar Schulz 1, Fabian Kiessling 1, Twan Lammers 1 1Uniklinik RWTH Aachen (UKA) Experimental Molecular Imaging (ExMI), Pauwelsstrasse 30, 52074 Aachen, Germany 2University of Urbino ‘Carlo Bo’ Department of Biomolecular Sciences, Urbino, Italy 3RWTH Aachen University Department of Biophysical and Education Engineering/BEE, Pauwelsstrasse 19, 52074 Aachen, Germany
#PW 02 / 20
Development of light-responsive MRI contrast agents Friederike Reeßing 1, Marc Stuart 2, Rudi Dierckx 1, Ben Feringa 2, Wiktor Szymanski 1 1University Medical Center Groningen Radiology, Hanzeplein 1, 9700 RB Groningen, Netherlands 2University of Groningen Stratingh Institute for Chemistry, Nijenborgh 4, 9747 AG Groningen, Netherlands
#PW 02 / 21
Fluorinated molecules enable temperature determination in MRS and MRI
Christian Bruns, Rainer Ringleb, Frederike Euchner, Ute Bommerich, Tim Herrmann, Johannes Bernarding, Markus Plaumann
Otto-von-Guericke-University Magdeburg Department for Biometrics and Medical Informatics, Leipziger Str. 44, 39120 Magdeburg, Germany
#PW 02 / 22
Multifunctional iron(III)-tannic molecular nanoparticles; A new promising theranostic nanomedicine platform
Saowalak Krungchanuchat 1,2, Titipun Thongtem 2, Somchai Thongtem 3, Chalermchai Pilapong 1 1Chiang Mai University Radiologic Technology, 110 Intrawaroroj road, Sriphoom,, Chiang Mai, Chiang Mai 50200, Thailand 2Chiang Mai University Chemistry, 239 Huay Keaw Road, Chiang Mai, Chiang Mai 50200, Thailand 3Chiang Mai University Physics and Material science, 239 Huay Keaw Road, Chiang Mai, Chiang Mai 50200, Thailand
#PW 02 / 23
L-Ferritin: a theranostic agent to target SCARA-5 postive cancer cells Bitonto Valeria, Gonella Gianluca, Alberti Diego, Aime Silvio, Geninatti-Crich Simonetta, Cutrin Juan Carlos
Molecular Biotechnology Center, Department of Molecular Biotechnologies and Sciences for the Health, University of Torino - Torino, Italy
#PW 02 / 24
Yb(III)AAZTA (H2O): a new generation of anionic ParaCEST complexes
Daniela Delli Castelli 1, Francesca Garello 1, Lorenzo Tei 2, Silvio Aime 1, Mauro Botta 2 1Univ Turin Molecular Biotechnology and health science, via nizza 52, I-10126 Turin, Italy 2Univ Piemonte Orientale DiSIT, Viale T Michel 11, I-15121 Alessandria, Italy
#PW 02 / 25
Perovskite Nanoparticles as MRI Contrast Agents Salim Khalfan Suroor Al Habsi 1,2, Graeme Stasiuk 2, M. Grazia Francesconi 1 1School of Mathematics and Physical Sciences Chemistry, Cotingham Road, HUll, HU6 7RX, United Kingdom 2School of Environmental Sciences / Life Science Biology, Cotingham Road, HUll, HU6 7RX, United Kingdom
Characterization of the novel PET tracer PI-2620 for the assessment of Tau pathology in Alzheimer’s disease and other tauopathies Felix Oden 1, Heiko Kroth 2, Hanno Schieferstein 1, Mathias Berndt 1, Andre Mueller 1, Francesca Capotosti 2, Jerome Molette 2, Tanja Juergens 2, Vincent Darmency 2, Heribert Schmitt-Willich 1, David Hickman 2, Gilles Tamagnan 3, Andrea Pfeifer 2, Ludger Dinkelborg 1, Andreas Muhs 2, Andrew Stephens 1 1Piramal Imaging R&D, Tegeler Str. 6-7, 13353 Berlin, Germany 2AC Immune R&D, EPFL Innovation Park, 1015 Lausanne, Switzerland 3Molecular NeuroImaging R&D, 60 Temple St, New Haven, 06510, United States
#PW 03 / 27
Characterization of 18F-labeled cyclic isoDGR and NGR peptides for tumour imaging Silvia Valtorta 1,2, Flavio Curnis 3, Francesco Sudati 2, Anna Maria Gasparri 3, Martina Fiocchi 3, Angelina Sacchi 3, Alessandro Gori 4, Luigi Gianolli 2, Rosa Maria Moresco 1,2, Angelo Corti 3,5 1University of Milano-Bicocca Department of Medicine and Surgery, Monza, Italy 2IRCCS San Raffaele Scientific Institute Experimental Imaging Center, Milano, Italy 3IRCCS San Raffaele Scientific Institute Division of Experimental Oncology, Milano, Italy 4CNR Institute of Chemistry of Molecular Recognition, Milano, Italy 5Vita Salute San Raffaele University, Milano, Italy
#PW 03 / 28
Tripodal ligands for Rapid Chelation of Gallium-68 at Neutral pH Price Thomas W1,2, Kubíček Vojtěch3, Böhmová Zuzana3, Hermann Petr3, Stasiuk Graeme1,2 1University of Hull, School of Life Sciences - Hull, United Kingdom 2University of Hull, Positron Emission Tomography Research Centre - Hull, United Kingdom 3Charles University, Faculty of Science - Prague 2, Czech Republic
#PW 03 / 29
Fully automated radiosynthesis of [18F]AV-1451, a tau specific radiotracer for imaging Alzheimer’s disease Linjing Mu 1, Livio Koenig 1, Gloria Pla 2, Annette Kraemer 2, Susanne Geistlich 2, Roger Schibli 2 1University Hospital Zürich Department of Nuclear Medicine, Raemistrasse 100, 8091 Zurich, Switzerland 2ETH Zurich Department of Chemistry and Applied Biosciences, Vladimir Prelog Weg 4, 8093 Zurich, Switzerland
#PW 03 / 30
Amino acid based chelators for gallium-68
Price Thomas W1,2, Harvey Peter3,4, Seeman Johanna2, Knight Madeleine3, Jones Jennifer3, Archibald Stephen2, Natrajan Louise3, Stasiuk Graeme1,2 1University of Hull, School of Life Sciences - Hull, United Kingdom 2University of Hull, Positron Emission Tomography Research Center - Hull, United Kingdom 3University of Manchester, Chemistry - Manchester, United Kingdom 4Massachusetts Institute of Technology - Cambridge, United States
#PW 03 / 31
Development of a new miRNA sensor. Skourti Eleni1, Zampetaki Anna2, Fruhwirth Gilbert O.1,3 1King's College London, Imaging Chemistry and Biology - London, United Kingdom 2King's College London, Cardiovascular Division - London, United Kingdom 3Comprehensive Cancer Imaging Centre King’s College London & UCL, King's College London - London, United Kingdom
#PW 03 / 32
MPI/MRI/fluorescence multimodal imaging nanoemulsion platform Geoffrey Prévot 1, Adina Lazar 2, Florence Ottones 3, Cyril Lorenzato 3, Stéphane Mornet 4, Philippe Barthélémy 1, Franck Couillaud 5, Gisčle Clofent-Sanchez 3, Mireille Blanchard-Desce 2, Sylvie Crauste-Manciet 1 1Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN : Régulations Naturelle et Artificielle, ChemBioPharm, 146 rue Léo Saignat, 30000 Bordeaux, France 2Univ. Bordeaux, CNRS UMR 5255 ISM, Institut des Sciences Moléculaires, 351 Cours de la Libération, 33400 Talence, France 3Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systčmes Biologiques, 14, 30000 Bordeaux, France 4Univ. Bordeaux, CNRS UPR 9048 ICMCB, Institut de Chimie de la Matičre Condensée de Bordeaux, 87, Avenue du Docteur Schweitzer, 33600 Pessac, France 5Univ. Bordeaux, IMOTION, EA 7435, 146 rue Léo Saignat, 30000 Bordeaux, France
#PW 03 / 33
Identification of a Peptide Probe that Specifically Binds to Kidney Injury Molecule-1 using Phage Display Uttapol Permpoon, Mohammad Enamul Haque, Byungheon Lee
Kyungpook National University Department of Biochemistry and Cell Biology, School of Medicine, Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea Republic (South)
#PW 03 / 34
Bioinspired hybrid nanoparticles for non invasive, guided drug delivery for the treatment of cardiovascular diseases George Loudos 1,2 1National Center for Scientific Research (NCSR) “Demokritos”, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, Patriarchou Grigoriou & Neapoleos, 15310 Athens, Greece 2BET Solutions, Alexandras Avenue, 11472 Athens, Greece
#PW 03 / 35
Development of a multimodal contrast agent for MRI and PET applications Chilla Satya1, Hallot Gauthier1, Lacroix Simon2, Doumont S2, Muller Robert N.1,3, Goldman Serge2,3, Vander Elst Luce1,3, Laurent Sophie1,3 1University of Mons, General, Organic and Biomedical Chemistry, NMR and Molecular Imaging - Mons, Belgium 2Hospital Erasme,, Laboratoire de Cartographie Fonctionnelle du Cerveau - Brussels, Belgium 3Centre for Microscopy and Molecular Imaging (CMMI), Molecular Imaging - Charleroi-Gosselies,, Belgium
#PW 03 / 36
The Synthesis and Validation of Multimodal PET/Fluorescence Zinc Sensing Probes as Potential Imaging Agents for Prostate Cancer Firth George, Price Thomas W, Clarke Mitchell, Sturge Justin, Stasiuk Graeme
University of Hull, School of Life Sciences - Hull, United Kingdom
#PW 03 / 37
Fluorescent RGD-targeted USPIO-loaded microbubbles as trimodal ultrasound, MRI and optical imaging probes Vera Paefgen, Lia Appold, Fabian Kiessling
University Hospital Aachen Experimental Molecular Imaging, Pauwelsstraße 30, 52074 Aachen, Germany
#PW 03 / 38
In Vivo Bacterial Imaging without Engineering; A Novel Probe-Based Strategy Facilitated by Endogenous Nitroreductase Enzymes Michael Stanton, Panos Lehouritis, Michelle Cronin, Mark Tangney
Cork Cancer Research Centre University College Cork, Cork T12XF62, Ireland
#PW 03 / 39
Dual-modal SERS/fluorescence AuNP probe for mitochondrial imaging
Charlotte Eling 1,2, Ali Adawi 1, Jean-Sebastien Bouillard 1, Graeme Stasiuk 2 1University of Hull School of Mathematics and Physical Sciences, Cottingham Road, Hull, HU6 7RX, United Kingdom 2University of Hull School of Life sciences, Cottingham Road, Hull, HU6 7RX, United Kingdom
MicroCT imaging in lung cancer mouse model. Evaluation of a semiquantitative quantification technique.
Anna Pujol Esclusa 1, Toni Jauset 2, Daniel Massó-Vallés 2, Laia Foradada 2, Juan Antonio Camara Serrano 1 1Vall d´Hebron Institut de Recerca Preclinical Imaging Platform, C/Nazaret, 115-117, 08035 Barcelona, Spain 2Vall d´Hebron Institut of Oncology (VHIO), Edifici Cellex, Hospital Vall d´Hebron, 08035 Barcelona, Spain
#PW 04 / 41
First in-vivo monitoring of hepatocellular carcinoma in mice with a photon counting detector for micro-CT imaging Loriane Portal 1, Franca Cassol 1, Mathieu Dupont 1, Yannick Boursier 1, Sylvie Richelme 2, Flavio Maina 2, Christian Morel 1 1Aix Marseille Université, CNRS/IN2P3, CPPM UMR 7346 13288, Marseille, France 2Aix Marseille Université, CNRS, IBDM UMR 7288 13288, Marseille, France
#PW 04 / 42
High performance PET detector based on a large volume monolithic LYSO Gonzalez-Montoro Andrea1, Aguilar Albert1, Cańizares Gabriel1, Conde Pablo1, Lamprou Efthimis1, Marti Rosana1, Sanchez Sebastian1, Sanchez Filomeno1, Correcher Carlos2, Benlloch Jose-Maria1, Gonzalez Antonio J.1 1Institute for Instrumentation in Molecular Imaging, i3M - Valencia, Spain 2Bruker Biospin - Valencia, Spain
#PW 04 / 43
MR-Compatible Bias Supply for Silicon Photo Multipliers
Becker Robert1, Buck Alfred2, Casella Chiara1, Commichau Volker1, di Calafiori Diogo1, Dissertori Günther1, Eleftheriou Afroditi3, Fischer Jannis1, Howard Alexander1, Ito Mikiko1, Khateri Parisa1, Lustermann Werner1, Oliver Josep4, Ritzer Christian1, Röser Ulf1, Rudin Markus5, Warnock Geoffrey3, Weber Bruno3, Wyss Matthias T.3 1ETH Zürich, Institut for Particle Physics - Zürich, Switzerland 2University of Zurich, Clinic of Nuclear Medicine - Zürich, Switzerland 3University of Zurich, Institute for Pharmacology and Toxicology - Zürich, Switzerland 4Universitat de Valčncia, Instituto de Física Corpuscular - Valencia, Spain 5ETH Zürich, Institute for Biomedical Engineering - Zürich, Switzerland
#PW 04 / 44
MR-Compatible Buck Converters
Satish Dhawan 1, Günther Dissertori 2, Jannis Fischer 2, Werner Lustermann 2, Christian Ritzer 2, Ulf Röser 2, Geoffrey Warnock 3 1Yale University Physics Department, New Haven, United States 2ETH Zürich Institute for Particle Physics, Zürich, Switzerland 3University of Zürich Institute for Pharmacology and Toxicology, Zürich, Switzerland
#PW 04 / 45
Comparing pharmacokinetics and tumour uptake of an EphA2 specific antibody and short chain variable fragment (scFv) in mouse models of glioma Simon Puttick 1,2, Bryan Day 3, Andrew Whittaker 1,4, Stephen Rose 2 1The University of Queensland Australian Institute for Bioengineering and Nanotechnology, Corner of College and Cooper Roads, St Lucia 4072, Australia 2CSIRO Health and Biosecurity, Herston 4029, Australia 3QIMR Berghofer Medical Research Institute, 300 Herston Roas, Herston 4006, Australia 4ARC Centre of Excellence in Convergent BioNano Science Queensland Node, The University of Queensland, St Lucia 4072, Australia
#PW 04 / 46
Initial evaluation of the Hyperion IID PET insert for simultaneous PET-MR imaging of atherosclerosis in rabbits using 18F-FDG Gebhardt Pierre1,2, Phinikaridou Alkystis2, Lavin Plaza Begona2, MacKewn Jane2, Weissler Björn1, Schug David1, Salomon André3, Marsden Paul2, Schulz Volkmar1,3, Botnar Rene2 1Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University - Aachen, Germany 2Division of Imaging Sciences and Biomedical Engineering, King's College London - London, United Kingdom 3Department of Oncology Solutions, Philips Research - Eindhoven, Netherlands
#PW 04 / 47
DoseWire: optical fiber-based real-time dosimetry for microCT and radiation therapy applications Emiliano D'agostino 1, Ria Bogaerts 2, Christian Vanhove 3, Greetje Vande Velde 4 1DoseVue NV, Ispralaan 37, 2400 Mol, Belgium 2Laboratory of Experimental Radiotherapy Oncology, Herestraat 49, 3000 Leuven, Belgium 3Institute Biomedical Technology Medical Imaging and Signal Processing, Gent, Belgium 4Biomedical MRI/ MoSAIC Imaging and Pathology, Herestraat 49, 3000 Leuven, Belgium
#PW 04 / 48
Depth of Interaction Detector Module for a Mouse Brain PET/MRI System
Christoph Parl, Armin Kolb, Fabian Schmidt, Bernd J. Pichler
Eberhard Karls University Tuebingen Werner Siemens Imaging Center, Roentgenweg 13, 72076 Tuebingen, Germany
#PW 04 / 49
High resolution computed tomography of paraffin embedded samples allows precise histological sectioning at predetermined regions of interest Jonas Albers 1,2, Giuliana Tromba 3, Frauke Alves 1,2,4, Christian Dullin 4,3 1Max Planck Institute for Experimental Medicine Molecular Biology of Neuronal Signals, Hermann-Rein-Str. 3, 37075 Goettingen, Germany 2University Medical Center Goettingen Dept. of Hematology and Medical Oncology, Robert-Koch-Straße 40, 37075 Goettingen, Germany 3Elettra-Sinchrotrone Trieste SYRMEP Beamline, Strada Statale 14 - km 163,5 in Area Science Park, 34149 Trieste, Italy 4University Medical Center Goettingen Institute for Diagnostic and Interventional Radiology, Robert-Koch-Straße 40, 37075 Goettingen, Germany
#PW 04 / 50
Virtual histology of pancreatic ductal adenocarcinoma by synchrotron microCT Mara Saccomano 1,2, Giuliana Tromba 2, Frauke Alves 1,3,4, Christian Dullin 2,3 1Max Planck Institut for Experimental Medicine Department of Molecular Biology of Neuronal Signals, Hermann-Rein Strasse, 3, 37075 Goettingen, Germany 2Elettra-Sincrotrone Trieste S.C.p.A, Strada Statale 14 - km 163,5 in AREA Science Park, 34149 Basovizza (Trieste), Italy 3University Medical Center Institute for Diagnostic and Interventional Radiology, Robert Koch Strasse, 40, 37075 Goettingen, Germany 4University Medical Center Department of Haematology and Medical Oncology, Robert Koch Strasse, 40, 37075 Goettingen, Germany
#PW 04 / 51
Small animal radiation dose from micro-CT Willekens Inneke, van Gompel Gert, Buls Nico, de Mey Johan
UZ Brussel Radiology - Jette, Belgium
#PW 04 / 52
CT scans reveal profound seasonal changes in the ossified skull of two mammals Javier Lazaro 1,2, Dina K. N. Dechmann 1,2, Scott Lapoint 1,3, Christian Dullin 4, Moritz Hertel 5, Jan R. E. Taylor 6, Karol Zub 7, Martin Wikelski 1,2 1Max Planck Institute for Ornithology Department of Migration and Immuno-ecology, Am Obstberg 1, 78315 Radolfzell, Germany 2University of Konstanz Department of Biology, 78457 Konstanz, Germany 3Lamont-Doherty Earth Observatory,Columbia University Department of Earth and Environmental Sciences, Palisades, New York 10964, United States 4University Hospital Göttingen Institute for Diagnostic and Interventional Radiology, 37075 Göttingen, Germany 5Max Planck Institute for Ornithology Department of Behavioural Neurobiology, 82319 Seewiesen, Germany 6University of Białystok Institute of Biology, 15-245 Białystok, Poland 7Mammal Research Institute, 17-230 Białowieża, Poland
Neuron type specific synapse quantification allows for the estimation of network activity patterns Egor Dzyubenko
Ruhr University Bochum Cell Morphology and Molecular Neurobiology, Universitätsstr. 150, 44780 Bochum, Germany
#PW 05 / 54
An innovative strategy to label Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) Alberti Diego1, Porta Stefano2, Tei Lorenzo3, Grange Cristina2, Camussi Giovanni2, Aime Silvio1, Geninatti-Crich Simonetta1 1University of Turin, Department of Molecular Biotechnology and Health Science - Turin, Italy 2University of Turin, Department of Medical Sciences - Torino, Italy 3University of Piemonte Orientale, Department of Environmental and Life Science - Alessandria, Italy
#PW 05 / 55
Investigation of tumor skin aggressiveness by elemental imaging and histology: a preliminary study Busser Benoit1,2,3, Moncayo Samuel 3, Trichard Florian 3, Pelascini Frédéric 4, Pinel Nicole 2, Charles Julie 2, Motto-Ros Vincent 3, Sancey Lucie1 1Institute for Advanced Biosciences Cancer targets and Experimental therapeutics - Grenoble, France 2CHU Grenoble Biochemistry Department - Grenoble, France 3Institute Light and Matter SpectroBio - Lyon, France 4CRITT Matériaux Alsace - Schiltigheim, France
#PW 05 / 56
pH-Response of Poly(Lactide-co-Glycolide) (PLGA) Nanoparticles Containing Hyaluronic acid for the Treatment of Osteoarthritis Luana Zerrillo 1,2, Ivo Que 1, Alan Chan 2, Luis J Cruz 1 1LUMC Radiology department, Albinusdreef 2, 2333 ZA LEIDEN, Netherlands 2Percuros, Drienerlolaan 5-Zuidhorst, 7522 NB Enschede, Netherlands
#PW 05 / 57
A model for Fluorescence by Unbound Excitation from Luminescence (FUEL) in biological tissues. Navnina Bhatia 1, Sophie Bouccara 1, Fabiane Sônego 1, Ioanna Theodorou 1, Alexandra Holland 1, Florian Rückerl 1, Spencer Shorte 1, Régis Tournebize 1,2,3 1Imagopole Institut Pasteur, 25-28 rue du Dr. Roux, 75015 Paris, France 2Pathogénie Microbienne Moléculaire Institut Pasteur, 25-28 rue du Dr. Roux, 75015 Paris, France 3INSERM U1202 Institut Pasteur, 25-28 rue du Dr. Roux, 75015 Paris, France
#PW 05 / 58
Bacteriochlorophylls as Near Infrared Photo-Switches for Oxygen Radical Formation Iddo Pinkas 1, Tianqi Sheng 2, Ilan Feine 2, Yoram Salomon 3, Avigdor Scherz 2 1Weizmann Institute of Science Chemical Research Support, 234 Herzl st, 76100 Rehovot, Israel 2Weizmann Institue of Science Plant Sciences, 76100 Rehovot, Israel 3Weizmann Institue of Science Biological Regulation, Rehovot, Israel
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Structurally distinct periodic and dynamic chromatin domains revealed by super-resolution fluorescence microscopy Kirti Prakash
Institute of Molecular Biology (IMB) Superresolution Microscopy, Ackermannweg 4, 55128 Mainz, Germany
#PW 05 / 61
High content imaging and analysis of cytotoxic protein uptake pathways and activity Nataliia Beztsinna 1, Maria B C de Matos 1, Christoph Heyder 2, Gero Leneweit 2, Enrico Mastrobattista 1, Robbert Jan Kok 1 1UIPS, Utrecht University Department of Pharmaceutics, Universiteitsweg 99, 3584 CG Utrecht, Netherlands 2ABNOBA GmbH, Hohenzollernstraße 16, 75177 Pforzheim, Germany
#PW 05 / 62
In vivo 2-photon microscopy for spatiotemporal characterization of biomarkers of metastatic disease severity Ulf Geisen, Maren Tietgen, Christine Desel, Olga Will, Sanjay Tiwari, Claus-Christian Glüer
Molecular Imaging North Competence Center Radiology and Neuroradiology, Am Botanischen Garten 14, 24118 Kiel, Germany
#PW 05 / 63
3D Quantification of myocardium injury in ischemia-reperfused mouse heart by photonics
Claire Crola da Silva, Yves Gouriou, Chris Berd, Lionel Augueul, Bruno Pillot, Emmanuelle Canet-Soulas, Michel Ovize, Gabriel Bidaux
CarMeN laboratory Inserm U1060, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, 59, boulverad Pinel, 69500 Bron, France
Translation of 68Ga-NOTA-UBI for nuclear imaging of infection in humans : toxicity, tolerability, pharmacokinetics and radiation dosimetry Thomas Ebenhan 1, Thavendran Govender 2, Jan Rijn Zeevaart 3,1, Mike Machaba Sathekge 1 1University of Pretoria Nuclear Medicine and Steve Biko Academic Hospital, crn Malherbe and Steve Biko Rd, Pretoria, 0001 South Africa 2Catalysis and Peptide Research Unit School of Health Sciences, Westville Campus, Durban, 3630 South Africa 3Preclinical Drug Development Platform Science and Technology, 11 Hofman Street, Potcheftroom, 2520 South Africa
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Assessing severity of Staphylococcus aureus-induced infective endocarditis by MRI Christian Schwarz 1, Verena Hoerr 1,2, Silke Niemann 3, Carina Hillgruber 4, Tobias Goerge 4, Georg Peters 3, Cornelius Faber 1 1University Hospital Muenster Department of Clinical Radiology, Albert-Schweitzer-Campus 1, Gebäude A16, 48149 Muenster, Germany 2Jena University Hospital Institute of Medical Microbiology, Erlanger Allee 101, 07747 Jena, Germany 3University Hospital Muenster Institute of Medical Microbiology, Domagkstraße 10, 48149 Muenster, Germany 4University Hospital Muenster Institute of Dermatology, von Esmarchstr. 58, 48149 Muenster, Germany
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In vivo imaging to explore the respiratory tract in a model of Bordetella pertussis infection using non-human primates Thibaut Naninck 1,2, Céline Mayet 1,2, Benoit Delache 1,2, Sébastien Langlois 1,2, Néla Klimova 1,2,3, Sabine Tricot 1,2, Vanessa Contreras 1,2, Peter Sebo 3, Coutte Loďc 4, Camille Locht 4, Roger Le Grand 1,2, Catherine Chapon 1,2 1CEA/DRF/iMETI/ImVA IDMIT, 18 route du panorama, 92265 Fontenay-aux-Roses, France 2Université Paris-Sud UMR E1, Orsay, France 3Institute of Microbiology, Czech Academy of Sciences Laboratory of Molecular Biology of Bacterial Pathogens, Videnska 1083, Prague, Czech Republic 4Institut Pasteur de Lille, Université de Lille Inserm U1019, CNRS UMR8204, Lille, France
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In vivo assessment of a dual antibiotic therapy regimen in a mouse model of S. aureus osteomyelitis by using MRI Verena Hoerr 1, Lorena Tuchscherr 1, Hélčne van de Vyver 2, Bettina Löffler 1 1Jena University Hospital Institute of Medical Microbiology, Erlanger Allee 101, 07747 Jena, Germany 2University Hospital Muenster Institute of Medical Microbiology, Domagkstr. 10, 48149 Muenster, Germany
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Development of a novel luminescent reporter for Listeria monocytogenes Ur Rahman Sadeeq1, Stanton Michael2, G Casey Pat3, Francis Kevin P.4, Tangney Mark5, Gahan Cormac G.m.3 1Alimentary Pharmabiotic Centre, University College Cork, Ireland - Cork, Ireland 2Cork Cancer Research Centre, Univrsity College Cork, Ireland - Cork, Ireland 3Alimentary Pharmabiotic Centre, University College Cork, Ireland, School of Microbiology - Cork, Ireland 4PerkinElmer, Alameda, California, United States of America - Califonia, United States 5Cork Cancer Research Centre, Univrsity College Cork - Cork, Ireland
In-depth characterization of a TCR-specific tracer for sensitive detection of tumor-directed transgenic T cells by immuno-PET Nahid Yusufi 1, Sabine Mall 2,3, Henrique Bianchi 2, Richard Klar 2, Stefan Audehm 2, Christian Peschel 2,3, Markus Schwaiger 1,3, Angela Krackhardt 2,3, Calogero D'alessandria 1 1Klinikum rechts der Isar, Technische Universität München Department of Nuclear Medicine, Ismaningerstr.22, 81675 Munich, Germany 2Klinikum rechts der Isar, Technische Universität München III. Medical Department, Ismaningerstr.22, 81675 Munich, Germany 3German Cancer Consortium of Translational Cancer Research (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany
#PW 07 / 70
Imaging of Synovial Fibroblasts migration in mice: Role of early cartilage degradation in Rheumatoid Arthritis Christiane Geyer 1, Jan Hillen 2,3, Marianne Heitzmann 2, Denise Beckmann 2, Christoph Bremer 4, Thomas Pap 2, Adelheid Korb-Pap 2 1University Hospital Muenster Department of Clinical Radiology, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany 2University Hospital Muenster Institute of Experimental Musculoskeletal Medicine, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany 3University Hospital Muenster Department of Anaesthesiology, Intensive Care and Pain Medicine, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany 4St. Franziskus Hospital Muenster Westphalian Centre for Radiology, Hohenzollernring 72, 48145 Muenster, Germany
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Magnetic particle imaging of islet transplantation in the liver and under the kidney capsule in mouse models
Ping Wang 1, Patrick Goodwill 2,3, Jeff Gaudet 3, Alana Ross 1, Elaine Y. Yu 2, Timothy Doyle 4, Christopher Contag 4,5, Andreas Clemmensen 6, Steven Conolly 2, Anna Moore 1 1Massachusetts General Hospital Radiology Department, 75, 13th Street, Charlestown, MA 02129, United States 2University of California at Berkeley Department of Bioengineering, 156 Stanley Hall, Berkeley, CA 94720, United States 3Magnetic Insight, Inc.,, 980 Atlantic Avenue, Alameda, CA 94501, United States 4Stanford University School of Medicine Department of Pediatrics, Stanford, CA 94395, United States 5Michigan State University Department of Biomedical Engineering, East Lansing, MI 48842, United States 6University of Copenhagen Department of Biomedical sciences, Copenhagen, Denmark
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Labelling CD8+ T-cells with Zr-89 for clinical PET imaging
Mylene Jansen 1, Cathelijne Frielink 2, Peter Laverman 2, Eric Visser 2, Otto Boerman 2, Erik Aarntzen 2 1University of Twente Technical Medicine, Drienerlolaan 5, 7522NB Enschede, Netherlands 2Radboudumc Radiology and Nuclear Medicine, Geert Grooteplein 10, 6500HB Nijmegen, Netherlands
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Multi-scale in vivo visualization of living mice with thrombotic and inflammatory responses by 8K CMOS sensor. Satoshi Nishimura
Jichi med Univ Center for Molecular Mediicne, yakushiji 3311-1, shimotsuke, Tochigi, Tochigi 3290498, Japan
[18F]FDOPA PET: Does neuroinflammation-related [18F]FDOPA uptake mask dopamine depletion in Parkinson’s Disease? Stefanie Vus 1,2,3, Johannes Zischler 4, Cathrin Rohleder 5,1, Boris Zlatopolskiy 1, Henning Boecker 3, Thomas Klockgether 3, Alexander Drzezga 2, Bernd Neumaier 1,4, Heike Endepols 1,2 1University Hospital of Cologne Institute of Radiochemistry and Experimental Molecular Imaging (IREMB), Kerpener Str. 62, 50937 Cologne, Germany 2University Hospital of Cologne Clinic of Nuclear Medicine, Kerpener Str. 62, 50937 Cologne, Germany 3German Centre for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany 4Jülich Research Center INM-5, Wilhelm-Johnen-Straße,, 52428 Jülich, Germany 5Central Institute of Mental Health Mannheim, 68159 Mannheim, Germany
#PW 08 / 75
CHANGES IN GLIAL CELL MORPHOLOGY, SOD1 DISTRIBUTION AND ELEMENTAL COMPOSITION IN THE BRAIN OF THE ALS hSOD1G93A RAT Stamenkovic Stefan1, Ducic Tanja2, Stamenkovic Vera1, Kranz Alexander3, Andjus Pavle1 1Center for laser microscopy, Faculty of Biology, University of Belgrade, Institute for Physiology and Biochemistry - Belgrade, Serbia and Montenegro 2CELLS – ALBA synchrotron light source - Cerdanyola del Valles, Barcelona, Spain 3Fraunhofer institute for cell therapy and immunology, Experimental imaging unit, Depertment for cell therapy - Leipzig, Germany
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INNATE IMMUNITY HELPS TO REVIVE EMBRYONAL PATHWAYS AFTER AN ISHEMIC STROKE IN ADULT MICE Gorup Dunja1, Škokić Siniša1, Pochet Roland2, Mitrečić Dinko1, Križ Jasna3, Gajovic Srecko1 1Croatian Institute for Brain Research, School of Medicine, University of Zagreb - Zagreb, Croatia 2Laboratory of Histopathology, Faculty of Medicine, Université Libre de Bruxelles - Brussels, Belgium 3Research Centre of Institute Universitaire En Santé Mentale and Department Of Psychiatry And Neuroscience, Laval University - Quebec City, Canada
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Investigating the temporal profile of imaging biomarkers in the cuprizone model of demyelination Bastian Zinnhardt 1, Michaël Belloy 2, Jasmien Orije 2, Inga B. Fricke 1,3, Sven Hermann 1, Annemie van der Linden 2, Andreas H. Jacobs 1,4 1University of Münster European Institute for Molecular Imaging (EIMI), Waldeyerstraße 15, 48149 Münster, Germany 2University of Antwerp Bio-Imaging Laboratory, Department of Biomedical Sciences, Antwerp, Belgium 3University of Toronto Image-Guided Therapy and Bioengineering Research Group, Institute of Biomaterials & Biomedical Engineering, Toronto Canada 4Evangelische Kliniken, Johanniter Hospital Department of Geriatrics, Bonn, Germany
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Exposure to intermittent hypoxia induces TLR2 expression in the mouse brain Polšek Dora1, Bago Marcell2, Živaljć Marija1, Križ Jasna3, Mitrečić Dinko1, Williams Steve C.4, Rosenzweig Ivana4, Gajovic Srecko1 1University of Zagreb, School of Medicine, Department of Histology and Embryology - Zagreb, Croatia 2Institute of Clinical Experimental Research, Semmelweis University - Budapest, Hungary 3Laval University, Faculty of Medicine - Quebec, Canada 4Sleep and Brain Plasticity Centre, Department of Neuroimaging, King's College London - London, United Kingdom
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Brain ischemic injury and intermittent hypoxia evaluation in the mouse by Tlr2, Gap43 and Casp3 bioluminescence imaging, micro CT and MRI Gajovic Srecko1, Gorup Dunja1, Polšek Dora1, Dobrivojevic Radmilovic Marina1, Škokić Siniša1, Sindjić Aleksandra1, Rosenzweig Ivana2, Križ Jasna3, Mitrečić Dinko1 1University of Zagreb School of Medicine, Croatian Institute for Brain Research - Zagreb, Croatia 2King's College London, Department of Neuroimaging - London, United Kingdom 3Laval University Faculty of Medicine, Dpt. of Psychiatry and Neuroscience - Quebec, Canada
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IN VIVO 1H MAGNETIC RESONANCE SPECTROSCOPY REVEALS HYPOTHALAMIC INFLAMMATION IN OVARIECTOMIZED OLD-AGE TG2576 MICE FOR ALZHEIMER DISEASE
Michaël Belloy 1, Firat Kara 1, An Langbeen 2, Steffen Roßner 3, Johan van Audekerke 1, Marleen Verhoye 1, Annemie van der Linden 1 1Bio-Imaging Lab FBD, Universiteitsplein 1, 2610 Wilrijk, Belgium 2VPB FBD, Universiteitsplein 1, 2610 Wilrijk, Belgium 3Paul Flechsig Institut für Hirnforschung Molekulare und zelluläre Mechanismen der Neurodegeneration, Liebigstr. 19, 04103 Leipzig, Germany
#PW 08 / 81
1.5T MRI reveals a hampered blood-brain barrier and CD4+ T cell infiltration in the presymptomatic hSOD1 G93A ALS rat model
Stefan Stamenkovic 1, Milos Jovanovic 1, Marko Dakovic 2, Pavle Andjus 1 1Faculty of Biology University of Belgrade Center for laser microscopy, Studentski trg 3, 11000 Belgrade, Serbia and Montenegro 2Faculty of Physical Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia and Montenegro
#PW 08 / 82
Divergence of [18F]-FDG and [11C]-PK11195 uptake in the brain of Non-Human Primates with carotid atherosclerosis
Vanessa di Cataldo 1, Joao Piraquive Agudelo 2, Michaël Verset 3, Adeline Paturet 3, Emmanuel Labaronne 1, Justine Debatisse 1, Emmanuelle Loizon 1, Franck Lamberton 2, Danielle Ibarrola 2, Franck Lavenne 2, Didier Le Bars 2, Hugues Contamin 3, Emmanuelle Canet-Soulas 1 1Univ Lyon, CarMeN Laboratory, INSERM U1060, INRA U1397, Université Lyon 1, INSA Lyon, Oullins, France 2CERMEP, Groupement Hospitalier Est, Bron, France 3Cynbiose, VetAgroSup Campus, Marcy l'Etoile, France
Impact of implanted human neural stem cells on functional and structural network changes in the brain after stroke Claudia Green 1, Anuka Minassian 1, Andreas Beyrau 1, Michael Diedenhofen 1, Stefanie Vogel 1, Dirk Wiedermann 1, Mathias Hoehn 1,2 1Max-Planck-Institut for Metabolism Research In-vivo-NMR, Gleueler Str. 50, 50931 Cologne, Germany 2Leiden University Medical Center Dept. Radiology, Leiden, Netherlands
#PW 09 / 85
Lacunar infarction, microbleeds, and brain network changes in a mouse model of vascular cognitive impairment.
Boehm-Sturm Philipp1, Kuchling Joseph2, Finke Carsten2, Foddis Marco3, Mueller Susanne1, Sassi Celeste3, Harms Christoph3, Koch Stefan Paul3, Dirnagl Ulrich3,4, Farr Tracy Deanne5 1Department of Experimental Neurology, Charité University Medicine, Center for Stroke Research Berlin (CSB), Charité Core Facility 7T Experimental MRIs - Berlin, Germany 2Berlin Center for Advanced Neuroimaging, NeuroCure Clinical Research Center Neuroimmunology and Berlin School of Mind and Brain, Humboldt University Berlin, Charité University Medicine, Department of Neurology - Berlin, Germany 3Charité University Medicine, Center for Stroke Research Berlin (CSB), Department of Experimental Neurology - Berlin, Germany 4NeuroCure, German Center for Neurodegenerative Diseases (DZNE), Berlin site - Berlin, Germany 5University of Nottingham, School of Life Sciences - Nottingham, United Kingdom
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Non-Invasive Longitudinal Anatomical and Metabolic MR characterization of Transgenic Amyotrophic Lateral Sclerosis SOD1G93A Mouse Model Weerasekera Akila1, Sima Diana2, van Damme Philip3, Dresselaers Tom4, van Huffel Sabine2, Himmelreich Uwe5 1KU Leuven - leuven, Belgium 2KU Leuven, Electrical Engineering – ESAT- STADIUS - leuven, Belgium 3KU Leuven, Vesalius Research Center - leuven, Belgium 4UZ Leuven, Radiology - leuven, Belgium 5KU Leuven, Biomedical MRI - leuven, Belgium
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Effect of a high-fat, high-sugar, high-cholesterol diet on cerebrovascular response in a mouse model of Alzheimer's Disease. Kristof Govaerts 1, Jessica Sternisa 1, Tom Dresselaers 2, Fred van Leuven 3, Uwe Himmelreich 1 1KU Leuven Imaging & Pathology, Herestraat 49, 3000 Leuven, Belgium 2UZ Leuven Radiology, Herestraat 49, 3000 Leuven, Belgium 3KU Leuven Human Genetics, Herestraat 49, 3000 Leuven, Belgium
#PW 09 / 88
Ultra-High resolution MRI and confocal fluorescence microscopy for the in vitro study of remyelination processes
Ińaki Osorio-Querejeta 1,2, Irantzu Llanera 3, Maider Muńoz-Culla 1,2, Ander Egimendia 3,1, Pedro Ramos-Cabrer 3,4, David Otaegui 1,2 1IIS Biodonostia 1. Grupo de esclerosis múltiple, Área de Neurociencias, 20009 Donostia-San Sebastián, Spain 2REEM: Spanish network on Multiple Sclerosis, Casanoves 143, 08028 Barcelona, Spain 3CIC biomaGUNE Plataforma de Espectroscopía Óptica, Paseo de Miramón 182, 20014 Donostia-San Sebastián, Spain 4Ikerbasque Basque Foundation for Science, 48011 Bilbao, Spain
#PW 09 / 89
Brain glucose metabolism in the A53T alpha-synuclein rAAV rat model for Parkinson’s disease: from univariate to multivariate FDG PET analysis Melissa Crabbé 1, Martijn Devrome 1, Anke van der Perren 2, Thomas Lavreys 1, Bart de Laat 1, Veerle Baekelandt 2, Michel Koole 1, Koen van Laere 1, Cindy Casteels 1 1Nuclear Medicine & Molecular Imaging Imaging & Pathology, Herestraat 49, 3000 Leuven, Belgium 2Laboratory for Neurobiology and Gene Therapy Department of Neurosciences, Kapucijnenvoer 33, 3000 Leuven, Belgium
#PW 09 / 90
Bioluminescence imaging visualizes osteopontin-induced neurogenesis and neuroblast migration in the mouse brain after stroke. Rebecca Rogall 1,2, Anton Pikhovych 1,2, Annika Bach 1,2, Sabine Ulrike Vay 1, Johannes Baermann 1, Mathias Hoehn 2, Sébastien Couillard-Després 3, Gereon Rudolf Fink 1,4, Michael Schroeter 1,2,4, Maria Adele Rueger 1,2,4 1University Hospital of Cologne Department of Neurology, Kerpener Str. 62, 50924 Cologne, Germany 2Max Planck Institute for Metabolism Research, Gleueler Str. 50, 50931 Cologne, Germany 3Spinal Cord Injury and Tissue Regeneration Center Salzburg Institute of Experimental Neuroregeneration, Strubergasse 21, 5020 Salzburg, Austria 4Research Centre Juelich Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), 52425 Juelich, Germany
#PW 09 / 91
IN VIVO STUDY OF THE SV2A PROTEIN IN THE KAINIC ACID EPILEPSY RAT MODEL Serrano Navacerrada Maria Elisa, Becker Guillaume, Bahri Mohamed Ali, Warnier Corentin, Aerts Joël, Mievis Frédéric, Giacomelli Fabrice, Lemaire Christian, Salmon Eric, Luxen Andre, Plenevaux Alain
University of Ličge, GIGA-CRC In vivo Imaging - Ličge, Belgium
#PW 09 / 92
EFFECT OF STROKE ON CEREBRAL PROTEINOPATHIES
Yemisci Muge1, Bolbos Radu2, Langlois Jean-Baptiste2, Uruk Gokhan1, Yilmaz-Ozcan Sinem1, Cho Tae-Hee3, Wiart Marlene4, Canet-Soulas Emmanuelle4, Dalkara Turgay1, Zimmer Luc5, Chauveau Fabien5 1Hacettepe University, Institute of Neurological Sciences and Psychiatry - Ankara, Turkey 2CERMEP-Imagerie du Vivant - Lyon, France 3Hospices Civils de Lyon - Lyon, France 4Univ. Lyon, CarMeN laboratory, INSERM U1028, INRA U1397, INSA-Lyon, Univ. Lyon 1 - Lyon, France 5Univ. Lyon, Lyon Neuroscience Research Center - Lyon, France
Evaluation of cellular and microenvironmental multidrug resistance in metastatic and optically imageable iRFP-expressing 4T1 breast carcinoma xenografts Okan Tezcan, Larissa Y. Rizzo, Fabian Kiessling, Twan Lammers
RWTH Aachen University Clinic Experimental Molecular Imaging, Pauwelsstrasse 30, 52074 Aachen, Germany
#PW 10 / 94
Combined diffuse light imaging tomographic (DLIT) and magnetic resonance imaging analysis of murine orthotopic and disseminated tumor models Sebastian Gehrig1, Fatih Alioglu1, Groza Diana2, Petra Heffeter2, Walter Berger2, Manfred Ogris1 1Laboratory of MacroMolecular Cancer Therapeutics, Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna - Vienna, Austria 2Institute for Cancer Research, Medical University of Vienna - Vienna, Austria
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11C-erlotinib PET experiments in mice bearing erlotinib-sensitive and -resistant tumor xenografts Alexander Traxl 1, Thomas Wanek 1, Taraneh Beikbaghban 2, Kushtrim Kryeziu 3, Severin Mairinger 1, Johann Stanek 1,4, Thomas Filip 1, Michael Sauberer 1, Claudia Kuntner 1, Walter Berger 2, Oliver Langer 1,4 1AIT Austrian Institute of Technology GmbH Health & Environment Department, Seibersdorf, Austria 2Medical University of Vienna Institute of Cancer Research, Vienna, Austria 3Oslo University Hospital HE - Norwegian Radium Hospital Institute for Cancer Research, Oslo, Norway 4Medical University of Vienna Department of Clinical Pharmacology, Vienna, Austria
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Combined Therapy of Oxaliplatin, 5‑Fluorouracil and Leucovorin (FOLFOX) Induces Increase of 3’-Deoxy-3’-[18F]Fluorothymidine in a Colorectal Cancer Xenograft Model but no Change in Mean Apparent Diffusion Coefficient Sonja Schelhaas 1, Lydia Wachsmuth 2, Astrid Heller 3, Natascha Rieder 3, Kathrin Heinzmann 4, Davina J. Honess 5, Donna-Michelle Smith 5, Sven Hermann 1, John Griffiths 5, Cornelius Faber 2, Richard Schneider 6, Eric O. Aboagye 4, Andreas H. Jacobs 1,7 1University of Münster European Institute for Molecular Imaging, Waldeyerstr. 15, 48149 Münster, Germany 2University Hospital of Münster Department of Clinical Radiology, 48149 Münster, Germany 3Roche Innovation Center Munich Pathology and Tissue Analytics, Penzberg, Germany 4Imperial College London Comprehensive Cancer Imaging Centre, London, United Kingdom 5Cancer Research UK Cambridge Institute, Cambridge, United Kingdom 6Merck KGaA, Darmstadt, Germany 7Johanniter Hospital Bonn Department of Geriatric Medicine, Bonn, Germany
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Knockdown of CSNK1D affect the growth and metastatic capacity of triple negative breast cancer cell lines
Isabelle Bar 1, Lionel Larbanoix 2,3, Ahamd Mehri 1, Sandy Haussy 1, Sophie Laurent 3,2, Paul Delrée 4, Jean-Luc Canon 5 1Institute of Pathology and Genetics/ Grand Hôpital de Charleroi Laboratory of Translational Oncology, Avenue Georges Lemaître 25, 6041 Gosselies, Belgium 2Université de Mons CMMI, Rue Adrienne Bolland, 8, 6041 Gosselies, Belgium 3Université de Mons NMR and Molecular Imaging Laboratory, Avenue Maistriau 19, 7000 Mons, Belgium 4Institute of Pathology and Genetics Department of Pathology, Avenue Georges Lemaître 25, 6041 Gosselies, Belgium 5Grand Hôpital de Charleroi Service of Oncology-Heamatology, Grand'Rue 3, 6000 Charleroi, Belgium
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Regulation of tumor engraftment, growth dynamics and glucose metabolism in anaplastic large cell lymphoma by CD147 Griessinger Christoph1, Steinhilber Julia2, Kohlhofer Ursula2, Pichler Bernd J.1, Fend Falko2, Bonzheim Irina2, Quintanilla-Martinez Leticia2 1University of Tübingen, Department of Preclinical Imaging and Radiopharmacy - Tübingen, Germany 2University of Tübingen, Department of Pathology - Tübingen, Germany
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Production of a transgenic bioluminescent mouse model overexpressing hLHR Tiziano Lottini 1, Jessica Iorio 1,2, Laura Carraresi 3, Claudia Duranti 4, Matteo Stefanini 5, Giulia Petroni 1, Serena Pillozzi 1, Ivo Noci 6, Annarosa Arcangeli 1 1University of Florence Department of experimental and clinical medicine, viale Morgagni 50, 50134 Florence, Italy 2Departement of Medical Biotechnologies, University of Siena Departement of Medical Biotechnologies, Siena, Italy 3D.I.V.A.L Toscana srl, Sesto Fiorentino, Firenze, Italy 4University of Florence Department of experimental and clinical medicine, Firenze, Italy 5D.I.V.A.L Toscana srl, Sesto Fiorentino, Firenze, Italy 6University of Florence Department of biomedical, experimental and clinical science, University of Florence, Firenze, Italy
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Dual contrast protocol for microCT scans in a colorectal tumor murine model
Pujol Esclusa Anna1, Chicote Ramos Irene2, Ramírez Corpas Lorena2,3, G. Palmer Héctor2, Camara Serrano Juan Antonio1 1Vall d´Hebron Institut de Recerca, Preclinical Imaging Platform - Barcelona, Spain 2Vall d´Hebron Institute of Oncology, Stem Cells and Cancer Group - Barcelona, Spain 3Vall d´Hebron Institute of Oncology, Gastrointestinal and endocrine tumors group - Barcelona, Spain
Magnetic hyperthermia generated by multifunctionalized MNPs enhances the therapeutic effect of gemcitabine in pancreatic tumors
Mourad Sanhaji 1, Julia Göring 1, Pierre Couleaud 2, Antonio Aires 2, Aitziber Cortajarena 2, José Courty 3, Adriele Prina-Mello 4, Marcus Stapf 1, Robert Ludwig 1, Yuri Vokov 4, Rodolfo Miranda 2, Ingrid Hilger 1 1University Hospital Jena Experimental Radiology, Am Klinikum 1, 07747 Jena, Germany 2Campus Universitario de Cantoblanco IMDEA Nanociencia, none, 28049 Madrid, Spain 3Université Paris EST Créteil Laboratoire CRRET, 61 Avenue du Général de Gaulle, 94010 Créteil, France 4Trinity College Dublin Nanomedicine and Molecular Imaging group, Dublin, Dublin Ireland
#PW 11 / 102
Image guided fluorescence surgery directed by pre-operative 3D multispectral optoacoustic tomography (MSOT). Marieke Stammes 1,2, Joanna Napp 3,4,5, Jing Claussen 6, Tim Devling 6, Alan Chan 2, Lioe-Fee de Geus-Oei 1, Frauke Alves 3,4,5 1Leiden University Medical Center Radiology, Albinusdreef, 2300RC Leiden, Netherlands 2Percuros, Drienerlolaan 5, 7522 NB Enschede, Netherlands 3Max-Planck-Institute of Experimental Medicine Molecular Biology of Neuronal Signals, Hermann-Rein-Straße, 37075 Göttingen, Germany 4University Medical Center Göttingen Institute of Interventional and Diagnostic Radiology, 37099 Göttingen, Germany 5University Medical Center Göttingen Haematology and Medical Oncology, Robert-Koch-Straße, 37099 Göttingen, Germany 6iTheraMedical GmbH, Zielstattstraße, 81379 München, Germany
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MRI-GUIDED THERMOSENSITIVE LIPOSOMAL DRUG DELIVERY FOR CANCER THERAPY Maral Amrahli, Michael Wright, Po-Wah So, Maya Thanou
King's College London Institute of Pharmaceutical Sciences, 150 Stamford Street, LONDON, SE1 9NH, United Kingdom
#PW 11 / 104
Immunotargeting of Galectin-3 in thyroid orthotopic tumors opens new challenge for thyroid cancer imaging in vivo de Rose Francesco1, Kuhlmann Michael2, Braeuer Miriam1, Reder Sybille1, Braesh-Andersen Sten3, Bartolazzi Armando4,5, Schwaiger Markus1, D’alessandria Calogero1 1Klinikum rechts der Isar, Technical University of Munich, Nuclear Medicine - Munich, Germany 2European Institute for Molecular Imaging - Münster, Germany 3Mabtech AB Research Laboratory - Stockholm, Sweden 4Karolinska Hospital, Cancer Center Karolinska, Pathology Research Laboratory - Stockholm, Sweden 5Sant'Andrea University Hospital, Pathology Research Laboratory - Rome, Italy
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Tumor- and inflammation-targeted E-Selectin Microbubbles for Improved Delivery of Doxorubicin and Budesonide Mengjiao Liu 1, Anshuman Dasgupta 1, Fabian Kiessling 1, Twan Lammers 1,2,3 1RWTH-aachen University Clinic Experimental Molecular Imaging, Pauwelsstrasse 20, 52074 Aachen, Germany 2University of Twente, Enschede Department of Targeted Therapeutics, Enschede, Netherlands 3Utrecht University Department of Pharmaceutics, Utrecht, Netherlands
#PW 11 / 106
EVALUATION OF BINDING AND UPTAKE OF RGD-TARGETED CORE-CROSSLINKED POLYMERIC MICELLES Federica de Lorenzi 1, Larissa Rizzo Yokota 1, Birgit Mardak 1, Matthias Bartneck 2, Maike Baues 1, Quizhi Hu 3, Jimmy Weterings 3, Cristianne Rijcken 3, Fabian Kiessling 1, Twan Lammers 1 1Uniklinik RWTH Aachen Institute for Experimental Molecular Imaging, Pauwelsstrasse 30, 52074 Aachen, Germany 2Uniklinik Department of Medicine III, Pauwelsstrasse 30, 52074 Aachen, Germany 3Cristal Therapeutics, Oxfordlaan 55, 6229EV Maastricht, Netherlands
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Effectiveness of oxygen release by ultrasound sensitive O2 microbubbles in solution and in vivo Agnieszka Drzał 1, Anthony Delalande 2, Chantal Pichon 2, Martyna Elas 1 1Jagiellonian University Department of Biophysics, Gronostajowa 7, 30-387 Kraków, Poland 2Centre de Biophysique Moléculaire, CNRS UPR4301 University of Orléans, Rue Charles Sadron, 45100 Orléans, France
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X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations Sara Lacerda 1, Slavka Kascakova 2, Alexandre Giuliani 2, Agnes Pallier 1, Pascal Mercere 2, Eva Jakab Toth 1, Matthieu Refregiers 2 1Centre de Biophysique Moleculaire, rue Charles Sadron, 45071 Orleans, France 2Synchrotron SOLEIL, L’Orme des Merisiers, 91190 Gif-sur-Yvette, France
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Feasibility and comparative study on different cationic and anionic thermosensitive liposomes on cell binding efficacy. Matteo Petrini 1, Wouter Lokerse 1, Olivia Merkel 2, Lars Lindner 1 1Ludwig-Maximilan University Universitiy Clinic Grosshadern, Marchioninistrasse 15, 81375 Munich, Germany 2Ludwig Maximilian University Pharmaceutical Technology and Biopharmaceuticals, Munich, Germany
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IMAGING MARKERS OF RESPONSE TO COMBINED BRAF - MEK INHIBITION IN MELANOMA Stefania Acciardo, Lionel Mignion, Bernard Gallez, Bénédicte F. Jordan
Université Catholique de Louvain Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Avenue Mounier 73, 1200 Brussels, Belgium
A novel antibody imaging strategy based on an innovative diagnostic marker Matteo Stefanini 1, Claudia Duranti 2, Laura Carraresi 1, Annarosa Arcangeli 2 1Company DI.V.A.L. Toscana S.R.L., Via Madonna del Piano 6, 50019 Sesto Fiorentino (FI), Italy 2University of Florence Department of experimental and clinical medicine, Viale Morgagni 50, 50134 Florence, Italy
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Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers
Jeannot Victor1, Mazzaferro Silvia2, Lavaud Jonathan1, Henri Maxime1, Josserand Veronique1, Coll Jean-Luc1, Lecommandoux Sébastien2, Schatz Christophe2, Hurbin Amandine1 1INSERM U1209, Institute for Advanced Biosciences - Grenoble, France 2CNRS UMR5629, Laboratoire Chimie des Polymčres Organiques - Pessac, France
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Antibody-based molecular imaging of PSMA-positive tumors in mice using immunoPET/MRI and Cerenkov luminescence imaging Anna-Maria Rolle 1, Florian C. Maier 1, Philipp Wolf 2, Kerstin Fuchs 1, Johannes Schwenck 1,3, Andreas Maurer 1, Bernd J. Pichler 1, Stefan Wiehr 1 1Werner Siemens Imaging Center Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany 2Department of Urology Medical Center, University of Freiburg, Breisacher Str. 66, 79106 Freiburg, Germany 3Department of Nuclear Medicine Eberhard Karls University Tuebingen, Otfried-Müller-Str. 16, 72076 Tuebingen, Germany
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Efficient theranostic of Cancer Stem Cells using combined delivery of drug-conjugated SWCNTs nanocarriers Achraf Al Faraj 1, Asma Sultana Shaik 2, Elaref Ratemi 3, Rabih Halwani 4 1American University of Science and Technology Radiologic Science, Faculty of Health Sciences, Beirut, Lebanon 2King Saud University Prince Naif Health Research Center, Riyadh Saudi Arabia 3Jubail Industrial College Chemical and Process Engineering Technology, Jubail Industrial City Saudi Arabia 4King Saud University Prince Naif Center for Immunology Research, College of Medicine, Department of Pediatrics, Riyadh Saudi Arabia
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Direct imaging of drug distribution and target engagement of the PARP Inhibitor Rucaparib Susanne Kossatz 1, Brandon Carney 1,2, Wolfgang Weber 1,3, Thomas Reiner 1,3 1Memorial Sloan Kettering Cancer Center Radiology, New York, NY 10065, United States 2Hunter College and PhD Program in Chemistry, The Graduate Center of the City University of New York Chemistry, New York, NY 10018, United States 3Weill Cornell Medical College Radiology, New York, NY 10065, United States
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Direct Cell Labelling with 89Zr(oxine)4 Allows In Vivo PET Imaging of Gamma-delta T-cells in a Breast Cancer Model Man Francis1, Lim Lindsay1, Shmeeda Hilary2, Gabizon Alberto2, Blower Philip J.1, Fruhwirth Gilbert O.1, T. M. de Rosales Rafael1 1King's College London, Department of Imaging Chemistry and Biology - London, United Kingdom 2Shaare Zedek Medical Center and Hebrew University, Oncology Institute, School of Medicine - Jerusalem, Israel
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Shedding new light on the mechanism of vascular targeted photodynamic therapy in vivo using raster-scan optoacoustic mesoscopy Katja Haedicke 1, Lilach Agemy 2, Murad Omar 3,4, Jonathan Coleman 5,6, Vasilis Ntziachristos 3,4, Avigdor Scherz 2, Jan Grimm 1,7,8 1Memorial Sloan Kettering Cancer Center Molecular Pharmacology Program, 1275 York Avenue, New York, NY 10065, United States 2Weizmann Institute of Science Department of Plant Sciences, Rehovot, Israel 3Technische Universitaet Muenchen Chair for Biological Imaging, Munich, Germany 4Helmholtz Zentrum Muenchen Institute for Biological and Medical Imaging, Munich, Germany 5Urology Service Department of Surgery, New York, NY United States 6Memorial Sloan Kettering Cancer Center Department of Urology, New York, NY United States 7Memorial Sloan Kettering Cancer Center Department of Radiology, New York, NY United States 8Weill Cornell Medical College Pharmacology Program and Department of Radiology, New York, NY United States
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Uncovering immune checkpoint blockade induced T cell activation with 18F-FDG PET/MRI in the spleens of tumor bearing mice Schörg Barbara1, Sonanini Dominik1, Schwenck Johannes1,2, Reischl Gerald1, Ehrlichmann Walter1, Kohlhofer Ursula3, Quintanilla-Martinez Leticia3, Röcken Martin4, la Fougere Christian2, Pichler Bernd J.1, Kneilling Manfred1,4 1Eberhard Karls University of Tuebingen, Werner Siemens Imaging Center, Department of preclinical Imaging and Radiopharmacy - Tuebingen, Germany 2Eberhard Karls University of Tuebingen, Department of Nuclear Medicine - Tuebingen, Germany 3Eberhard Karls Univeristy of Tuebingen, Department of Pathology - Tuebingen, Germany 4Eberhard Karls Univeristy of Tuebingen, Department of Dermatology - Tuebingen, Germany
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[18F]FAZA as PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study. Dall'angelo Sergio1, Fleming Ian2, McKiddie Fergus3, Murray Graeme4, Baio Gabriella2,3, Almulhim Zayed Saad A1, Zanda Matteo1, Samuel Leslie3 1University of Aberdeen, Kosterlitz Centre for Therapeutics, School of Medicine, Medical Sciences and Nutrition - Aberdeen, United Kingdom 2University of Aberdeen, Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences and Nutrition - Aberdeen, United Kingdom 3Aberdeen Royal Infirmary, Oncology & Radiology - Aberdeen, United Kingdom 4University of Aberdeen, School of Medicine, Medical Sciences and Nutrition - Aberdeen, United Kingdom
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Towards the development of non-invasive measures of breast cancer risk: image analysis of digital breast tomosynthesis mammograms and tissue lobule content Jonine Figueroa 1, Calum Gray 2, Giorgos Papanastasiou 2, Victor Gonzalez-Castro 2, Nick Polydorides 3, Andrew Evans 4, Sarah Vinnicombe 4 1University of Edinburgh Usher Institute of Population Health Sciences and Informatics, Teviot Place, Edinburgh, EH89AG, United Kingdom 2University of Edinburgh Clinical Research Imaging Centre, 47 Little France, Edinburgh, EH16 4TJ, United Kingdom 3University of Edinburgh School of Engineering, Alexander Graham Bell King’s Buildings, Edinburgh, EH9 3JL, United Kingdom 4University of Dundee School of Medicine, Ninewells Hospital and Medical School, Dundee, DD1 9SY, United Kingdom
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Whole body Diffusion weighted MRI in the detection of skeletal metastasis. Our experience with 3 Tesla MRI Jamal Abdulkatim
Consultant Radiologist Radiology department, George Eliot Hospital, College street, Nuneaton, CV 10 7 DJ, United Kingdom
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Investigation of novel molecular classifiers to identify high risk early stage colorectal cancer patients Joanna Cappell 1, Eline van Roekel 2, Nikkie Beukers 3, Kathleen Daenen 3, Matty Weijenberg 2, Ron Heeren 1, Manon van Engeland 3 1Maastricht University M4I Institute, Universiteitsingel 50, 6229ER Maastricht, Netherlands 2Maastricht University Department of Epidemiology, Peter Debyeplein 1, 6229HA Maastricht, Netherlands 3Maastricht University Department of Pathology, Peter Debyelaan 25, 6229HX Maastricht, Netherlands
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